Depo-Medrol (Methylprednisolone acetate) is an anti-inflammatory glucocorticoid that is administered to relieve pain from rheumatoid arthritis and bursitis, severe lower back pain or dermatologic disorders. The FDA has approved use of the corticosteroid injection into a muscle, a joint, or a lesion. The FDA has not approved the use of Depo-Medrol as an epidural injection for low back pain or sciatica, though many physicians still administer it through this off-label use.

It is alleged that there have been 356 deaths and 15,000 adverse events attributed to Depo-Medrol between 1998 and 2002. Pfizer, the maker of Depo-Medrol, does not advise Epidural/Intrathecal administration (injection into spinal cord or vein) of Depo-Medrol and reports the following severe medical events associated with this usage: Arachnoiditis, Meningitis, Paraparesis/paraplegia, bowel/bladder dysfunction, seizures, headaches, and more. Other reported side effects of Depo-Medrol include congestive heart failure, osteoporosis, peptic ulcer, and convulsions.

Depo-Medrol was originally introduced for relieving pain in animals; the drug is still used by veterinarians to relieve seasonal itching and inflammation in pets - primarily dogs!

Pfizer, who manufacturers and markets Depo-Medrol (previously Pharmacia and Upjohn) recommends Depo-Medrol for a wide range of disorders including: Respiratory diseases, endocrine disorders, dermatologic diseases such as Stevens-Johnson syndrome (SJS), osteoarthritis, rheumatoid arthritis, bursitis, severe asthma, allergic rhinitis, drug hypersensitivity reactions, leukemia, lymphoma, systemic lupus, hematologic disorders, and more.

For more information on Depo-Medrol prescriptions, please [Click Here]

Register your Depo-Medrol Complaint

If you or a loved one has suffered from severe side effects or death, you may qualify for damages or remedies that may be awarded in a possible class action lawsuit. Please click here to fill in our form to submit your complaint.

Reader Comments

Posted by
Christopher MC
I was administered a methylprednisolone injection for a labral tear in my hip . I was not warned of any of the side effects I am experiencing now which include low libido and zero interest in sexual intercourse , extreme difficulty in arousal and ED. The side effects occurred almost immediately after my procedure .

Posted by
Lori M
I received a Depo-Medrol injection in my ankle for advanced osteoarthritis on 6-1-16. By 6-6-16 , I was being treated with antibiotics for a severe upper respiratory infection and laryngitis. I completed the course of antibiotics. The antibiotics were in my system til 6-16-16. By 6-28-16, I was sick again with the same or worse symptoms. I have been placed on a different antibiotic. As of 7-1-16, I have not improved. I have phoned my pharmacist, my primary doctor and the orthopedic specialist who did the injection, trying to get answers to my concerns...has my immune system been compromised I going to keep getting sick. I am usually a very healthy person. I am 56 years old and I take no regular medication.

Posted by
Rhode Island
I was given a Depo-Medrol epidural on 7-30-09. Since then, I've had severe hormonal disturbances, migraines, extreme fatigue, heart palpitations, and have had to be rushed to the ER. (where they did nothing) After 2 1/2 months of hell, I've been diagnosed with Hashimoto's disease. (my thyroid is making anti-bodies) & I'll probably have to be treated for life for this issue. ALL OF THIS began after that shot. Also, the shot was NOT necessary. It was a HIP issue and they insisted that the pain I was having was caused by a disc bulge they found.

Posted by
Bilateral leg pain, stiffness and on pain meds. during day and increase need each day. Unable to work without discomfort/pain without meds and then go home and can not do anything but rest. Made my arthritic knee pain severe enough I was on oxycontin and then had to have a partial knee replacement. The pain post op was hard to control and 24 hours post op I coded because my body could not take anymore..and I was still in pain. I have been on antidepressants to help me. I cry daily with little provacation. I am also an RN.

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