According to an investigative report by ABC News, Mark Jacoby of New York and Anne Coffman of Maine, are both wheelchair bound as a result of being exposed to high levels of the mineral zinc – also known as zinc poisoning. Zinc poisoning interferes with the ability of the body to absorb copper. Both Jacoby and Coffman, and their respective physicians reportedly believe that their health problems are a result of the zinc found in Fixodent.
In a paper, published in Neurology in 2008, researchers at the University of Texas Southwestern Medical Center in Dallas, state, "Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease." In 2009 Proctor & Gamble updated the warning label on Fixodent stating that "prolonged zinc intake may be linked to adverse health effects."